PUBLICATIONS

First Author

Information-driven docking for TCR-pMHC complex prediction

Frontiers in Immununology 12, 686127 (2021)

T PEACOCK, B CHAIN

An expanded benchmark set of TCR-pMHC structures was used to compare the success of four protein-protein docking platforms in the context of TCR-pMHC modelling when provided with varying levels of binding interface information.

Decombinator V4: an improved AIRR-C compliant-software package for T-cell receptor sequence annotation

Bioinformatics 37 (6), 876-878 (2021)

T PEACOCK, JM HEATHER, T RONEL, B CHAIN

Details the improvements in accuracy, compatibility, and useability in Decombinator V4, a tool for rapid annotation of large T cell receptor sequence datasets.

Quantitative analysis of the T cell receptor repertoire

Methods in Enzymology 629, 465-492 (2019)

I UDDIN, A WOOLSTON, T PEACOCK, K JOSHI, M ISMAIL, T RONEL, C HUSOVSKY, B CHAIN

Detailed protocols for the experimental and computational pipelines used by the Chain lab for TCR repertoire analysis using the Decombinator software platform.

Contributing Author

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

iScience 26 (6), 106937 (2023)

M MILIGHETTI, Y PENG, C TAN, M MARK ET AL.

Analysis of the TCR repertoire in SARS-COV-2 infection, examining the expansion of specific T cell populations during the early immune response.

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Nature Medicine 25, 1549–1559 (2019)

K JOSHI, M ROBERT DE MASSY, M ISMAIL ET AL.

Analysis of the TCR repertoire in non-small-cell lung cancer (NSCLC), examining the correlation between TCR abundance and the number of mutations found in subdivided tumor regions.